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Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws
Joint Authors
Zheng, Li Wu
Yu, Ru Qing
Rao, Nian Jing
Wang, Jing Yi
Leung, Yiu Yan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model.
Materials and Methods.
Twenty C57BL/6N female mice were randomly assigned to two groups.
All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks.
Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control.
All animals were sacrificed four weeks after pulpal exposure, and the mandibles were harvested for radiological and histomorphometrical analysis.
Results.
Micro computed tomography (μ-CT) examination demonstrated that periapical diseases significantly increased alveolar bone resorption, and the resorption was greatly attenuated by ZA treatment.
Concurrent ZA therapy significantly increased bone density and histological osteocyte necrosis in the presence of periapical lesions.
Conclusion.
ZA treatment reduced bone absorption resulting from periapical disease but increased the risk of developing MRONJ in the ovariectomized mouse model.
American Psychological Association (APA)
Rao, Nian Jing& Wang, Jing Yi& Yu, Ru Qing& Leung, Yiu Yan& Zheng, Li Wu. 2017. Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134020
Modern Language Association (MLA)
Rao, Nian Jing…[et al.]. Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1134020
American Medical Association (AMA)
Rao, Nian Jing& Wang, Jing Yi& Yu, Ru Qing& Leung, Yiu Yan& Zheng, Li Wu. Role of Periapical Diseases in Medication-Related Osteonecrosis of the Jaws. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134020