Mechanism by which TRAF6 Participates in the Immune Regulation of Autoimmune Diseases and Cancer
Joint Authors
Wang, Jingjing
Wu, Xinjie
Jiang, Mengyu
Tai, Guixiang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase, is a signal transduction molecule shared by the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) family and the TNFR superfamily.
TRAF6 has a unique TRAF domain and RING finger domain that mediate intracellular signaling events.
In the immune system, TRAF6-mediated signaling has been shown to be critical for the development, homeostasis, and activation of a variety of immune cells, including B cells, T cells, dendritic cells, and macrophages.
Although the pathogenesis and etiology of autoimmune diseases and cancer are not fully understood, it is worth noting that existing studies have shown that TRAF6 is involved in the pathogenesis and development of a variety of these diseases.
Herein, we reviewed the role of TRAF6 in certain immune cells, as well as the function and potential effect of TRAF6 in autoimmune diseases and cancer.
Our review indicates that TRAF6 may be a novel target for autoimmune diseases and cancer.
American Psychological Association (APA)
Wang, Jingjing& Wu, Xinjie& Jiang, Mengyu& Tai, Guixiang. 2020. Mechanism by which TRAF6 Participates in the Immune Regulation of Autoimmune Diseases and Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1134024
Modern Language Association (MLA)
Wang, Jingjing…[et al.]. Mechanism by which TRAF6 Participates in the Immune Regulation of Autoimmune Diseases and Cancer. BioMed Research International No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1134024
American Medical Association (AMA)
Wang, Jingjing& Wu, Xinjie& Jiang, Mengyu& Tai, Guixiang. Mechanism by which TRAF6 Participates in the Immune Regulation of Autoimmune Diseases and Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1134024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134024