New Insights into the Epigenetics of Hepatocellular Carcinoma
Joint Authors
Wahid, Braira
Ali, Amjad
Rafique, Shazia
Idrees, Muhammad
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Hepatocellular Carcinoma (HCC) is one of the most predominant malignancies with high fatality rate.
This deadly cancer is rising at an alarming rate because it is quite resistant to radio- and chemotherapy.
Different epigenetic mechanisms such as histone modifications, DNA methylation, chromatin remodeling, and expression of noncoding RNAs drive the cell proliferation, invasion, metastasis, initiation, progression, and development of HCC.
These epigenetic alterations because of potential reversibility open way towards the development of biomarkers and therapeutics.
The contribution of these epigenetic changes to HCC development has not been thoroughly explored yet.
Further research on HCC epigenetics is necessary to better understand novel molecular-targeted HCC treatment and prevention.
This review highlights latest research progress and current updates regarding epigenetics of HCC, biomarker discovery, and future preventive and therapeutic strategies to combat the increasing risk of HCC.
American Psychological Association (APA)
Wahid, Braira& Ali, Amjad& Rafique, Shazia& Idrees, Muhammad. 2017. New Insights into the Epigenetics of Hepatocellular Carcinoma. BioMed Research International،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1134058
Modern Language Association (MLA)
Wahid, Braira…[et al.]. New Insights into the Epigenetics of Hepatocellular Carcinoma. BioMed Research International No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1134058
American Medical Association (AMA)
Wahid, Braira& Ali, Amjad& Rafique, Shazia& Idrees, Muhammad. New Insights into the Epigenetics of Hepatocellular Carcinoma. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1134058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134058