![](/images/graphics-bg.png)
Clinical Applications of Immunotherapy Combination Methods and New Opportunities for the Future
Author
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In the last decade, we have gained a deeper understanding of innate immune system.
The mechanism of the continuous guarding of progressive mutations happening in a single cell was discovered and the production and the recognition of tumor associated antigens by the T-cells and elimination of numerous tumors by immune-editing were further understood.
The new discoveries on immune mechanisms and its relation with carcinogenesis have led to development of a new class of drugs called immunotherapeutics.
T lymphocyte-associated antigen 4, programmed cell death protein 1, and programmed cell death protein ligand 1 are the classes drugs based on immunologic manipulation and are collectively known as the “checkpoint inhibitors.” Checkpoint inhibitors have shown remarkable antitumor efficacy in a broad spectrum of malignancies; however, the strongest and most durable immune responses do not last long and the more durable responses only occur in a small subset of patients.
One of the solutions which have been put forth to overcome these challenges is combination strategies.
Among the dual use of methods, a backbone with either PD-1 or PD-L1 antagonist drugs alongside with certain cytotoxic chemotherapies, radiation, targeted drugs, and novel checkpoint stimulators is the most promising approach and will be on stage in forthcoming years.
American Psychological Association (APA)
Esin, Ece. 2017. Clinical Applications of Immunotherapy Combination Methods and New Opportunities for the Future. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134073
Modern Language Association (MLA)
Esin, Ece. Clinical Applications of Immunotherapy Combination Methods and New Opportunities for the Future. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134073
American Medical Association (AMA)
Esin, Ece. Clinical Applications of Immunotherapy Combination Methods and New Opportunities for the Future. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134073