Prognostic Role of MicroRNA 222 in Patients with Glioma: A Meta-analysis
Joint Authors
Song, Yanlin
Xu, Jianguo
Zhang, Jing
He, Min
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Several studies have focused on the prognostic role of microRNA 222 in glioma.
But different conclusions were drawn by these studies.
We aimed to systematically evaluate the role of microRNA 222 in glioma by conducting a meta-analysis.
Methods.
A systematic literature search until January 2020 was conducted in Web of Science, EMBASE, Cochrane Library, PubMed, and China National Knowledge Infrastructure.
The general characteristics and relevant data of nine articles were extracted.
Hazard ratios (HRs) with 95% confidence intervals (CIs) were applied to evaluate the prognostic role of microRNA 222 in glioma.
The primary outcomes were overall survival (OS) and disease-free survival (DFS).
Results.
Nine articles (11 data sets) with 1564 patients were included.
We systematically evaluated the role of microRNA 222 for OS and DFS in glioma patients (HR for OS=1.72; 95% CI, 1.31-2.26; p=0.001; HR for DFS=1.02; 95% CI, 0.86-1.22; p=0.032).
Subgroup analyses were performed according to the sources of patients, the types of the samples, the stages of the tumors, the methods for detecting the microRNA 222, and the sample size.
No significant publication bias was found.
Conclusion.
In conclusion, our study provided evidence that a high expression of microRNA 222 was related to worse overall survival in glioma patients.
However, given the limited study number, more high-quality studies are warranted in the future.
American Psychological Association (APA)
Song, Yanlin& Zhang, Jing& He, Min& Xu, Jianguo. 2020. Prognostic Role of MicroRNA 222 in Patients with Glioma: A Meta-analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1134107
Modern Language Association (MLA)
Song, Yanlin…[et al.]. Prognostic Role of MicroRNA 222 in Patients with Glioma: A Meta-analysis. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1134107
American Medical Association (AMA)
Song, Yanlin& Zhang, Jing& He, Min& Xu, Jianguo. Prognostic Role of MicroRNA 222 in Patients with Glioma: A Meta-analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1134107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134107