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The Association between Hyperhomocysteinemia and Thoracoabdominal Aortic Aneurysms in Chinese Population
Joint Authors
Deng, Jianqing
Liu, Jie
Cao, Long
Wang, Qun
Zhang, Hongpeng
Liu, Xiaoping
Guo, Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To shed light on the association between hyperhomocysteinemia (HHcy) and thoracoabdominal aortic aneurysms (TAAAs).
Methods.
From July 2013 to March 2017, we conducted a matched case–control study involving individuals who presented to the Chinese People’s Liberation Army General Hospital and underwent thoracoabdominal magnetic resonance angiography or computed tomography angiography.
A total of 73 patients with TAAAs were enrolled in the case group, and 219 sex-matched subjects without TAAAs were included in the control group.
We then examined the relationship between HHcy and TAAAs by logistic regression models and subgroup as well as interaction analyses.
Results.
Serum total homocysteine (tHcy) concentrations and the proportion of HHcy were significantly higher in the patients with TAAAs than in those without TAAAs (P<0.001).
Furthermore, the multivariate logistic regression models indicated that participants with HHcy had a 2.14-fold higher risk of TAAAs than those with a normal serum tHcy level (adjusted odds ratio (OR), 2.14; 95% confidence interval, 1.00–4.56).
Similarly, each 1 μmol/L increase in the serum tHcy concentration was associated with a 4% higher risk of TAAAs (adjusted OR, 1.04; 95% confidence interval, 1.00–1.07).
Subgroup analyses indicated that HHcy tended to be associated with a greater risk of TAAAs in all stratified subgroups (adjusted ORs>1).
Furthermore, the interaction analyses revealed no interactive role in the association between HHcy and TAAAs.
Conclusions.
The present case–control study suggests that HHcy is an independent risk factor for TAAAs.
Larger prospective cohort studies are warranted to validate these findings.
American Psychological Association (APA)
Deng, Jianqing& Liu, Jie& Cao, Long& Wang, Qun& Zhang, Hongpeng& Liu, Xiaoping…[et al.]. 2020. The Association between Hyperhomocysteinemia and Thoracoabdominal Aortic Aneurysms in Chinese Population. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134112
Modern Language Association (MLA)
Deng, Jianqing…[et al.]. The Association between Hyperhomocysteinemia and Thoracoabdominal Aortic Aneurysms in Chinese Population. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1134112
American Medical Association (AMA)
Deng, Jianqing& Liu, Jie& Cao, Long& Wang, Qun& Zhang, Hongpeng& Liu, Xiaoping…[et al.]. The Association between Hyperhomocysteinemia and Thoracoabdominal Aortic Aneurysms in Chinese Population. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134112