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Beneficial Effects of 6-Month Supplementation with Omega-3 Acids on Selected Inflammatory Markers in Patients with Chronic Kidney Disease Stages 1–3
Joint Authors
Manitius, Jacek
Pluta, Agnieszka
Stróżecki, Paweł
Kęsy, Jacek
Lis, Kinga
Sulikowska, Beata
Sypniewska, Grazyna
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Chronic kidney disease (CKD) is accompanied by inflammation.
The aim of this study was to evaluate the effect of 6-month supplementation with omega-3 acids on selected markers of inflammation in patients with CKD stages 1–3.
Methods.
Six-month supplementation with omega-3 acids (2 g/day) was administered to 87 CKD patients and to 27 healthy individuals.
At baseline and after follow-up, blood was taken for C-reactive protein (CRP) and monocyte chemotactic protein-1 (MCP-1) concentration and white blood cell (WBC) count.
Serum concentration of omega-3 acids—eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA)—was determined using gas chromatography.
And 24-hour urinary collection was performed to measure MCP-1 excretion.
Results.
After six-month omega-3 supplementation, ALA concentration increased in CKD patients and in the reference group, while EPA and DHA did not change.
At follow-up, a significant decrease in urinary MCP-1 excretion in CKD (p=0.0012) and in the reference group (p=0.001) was found.
CRP, serum MCP-1, and WBC did not change significantly.
The estimated glomerular filtration rate (eGFR) did not change significantly in the CKD group.
Conclusions.
The reduction of urinary MCP-1 excretion in the absence of MCP-1 serum concentration may suggest a beneficial effect of omega-3 supplementation on tubular MCP-1 production.
Trial Registration.
This study was registered in ClinicalTrials.gov (identifier: NCT02147002).
American Psychological Association (APA)
Pluta, Agnieszka& Stróżecki, Paweł& Kęsy, Jacek& Lis, Kinga& Sulikowska, Beata& Sypniewska, Grazyna…[et al.]. 2017. Beneficial Effects of 6-Month Supplementation with Omega-3 Acids on Selected Inflammatory Markers in Patients with Chronic Kidney Disease Stages 1–3. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134115
Modern Language Association (MLA)
Pluta, Agnieszka…[et al.]. Beneficial Effects of 6-Month Supplementation with Omega-3 Acids on Selected Inflammatory Markers in Patients with Chronic Kidney Disease Stages 1–3. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1134115
American Medical Association (AMA)
Pluta, Agnieszka& Stróżecki, Paweł& Kęsy, Jacek& Lis, Kinga& Sulikowska, Beata& Sypniewska, Grazyna…[et al.]. Beneficial Effects of 6-Month Supplementation with Omega-3 Acids on Selected Inflammatory Markers in Patients with Chronic Kidney Disease Stages 1–3. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134115