Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair
Joint Authors
Huh, Youngbuhm
Yeo, Seung Geun
Kim, Min-Sik
Jung, Junyang
Shefa, Ulfuara
Song, In Ok
Jeong, Na Young
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
To date, three main gasotransmitters, that is, hydrogen sulfide (H2S), carbon monoxide (CO), and nitric oxide (NO), have been discovered to play major bodily physiological roles.
These gasotransmitters have multiple functional roles in the body including physiologic and pathologic functions with respect to the cellular or tissue quantities of these gases.
Gasotransmitters were originally known to have only detrimental and noxious effects in the body but that notion has much changed with years; vast studies demonstrated that these gasotransmitters are precisely involved in the normal physiological functioning of the body.
From neuromodulation, oxidative stress subjugation, and cardiovascular tone regulation to immunomodulation, these gases perform critical roles, which, should they deviate from the norm, can trigger the genesis of a number of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).
The purpose of this review is to discuss at great length physical and chemical properties and physiological actions of H2S, NO, and CO as well as shedding light on recently researched molecular targets.
We particularly put emphasis on the roles in neuronal inflammation and neurodegeneration and neuronal repair.
American Psychological Association (APA)
Shefa, Ulfuara& Yeo, Seung Geun& Kim, Min-Sik& Song, In Ok& Jung, Junyang& Jeong, Na Young…[et al.]. 2017. Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair. BioMed Research International،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1134119
Modern Language Association (MLA)
Shefa, Ulfuara…[et al.]. Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair. BioMed Research International No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1134119
American Medical Association (AMA)
Shefa, Ulfuara& Yeo, Seung Geun& Kim, Min-Sik& Song, In Ok& Jung, Junyang& Jeong, Na Young…[et al.]. Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1134119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134119