Histone Deacetylase Inhibition Attenuates Aortic Remodeling in Rats under Pressure Overload
Joint Authors
Jung, Hanna
Lee, Eunjo
Kim, Inkyeom
Kim, Gun Jik
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The use of histone deacetylase (HDAC) inhibitor is a novel therapeutic strategy for cardiovascular disease.
Studies have shown that many HDAC inhibitors have the ability to reduce the aortic remodeling in various animal models.
We hypothesized that the HDAC inhibitor, MGCD0103 (MGCD), attenuates aortic remodeling in rats under pressure overload-induced by transverse aortic constriction (TAC).
The aortic ring tension analysis was conducted using the thoracic aorta.
Sections of the aorta were visualized after hematoxylin and eosin, trichrome, and Verhoeff-van Gieson staining, and immunohistochemistry.
The expression of genes related to aortic remodeling (αSMA, Mmp2, and Mmp9) and angiotensin receptors (Agtr1 and Agtr2) was determined by quantitative real-time polymerase chain reaction.
There was a significant decrease in relaxation of the aorta when treated with MGCD.
Fibrosis of the aortic wall and expression of angiotensin receptors increased in TAC rats, which was attenuated by MGCD.
These results indicate that MGCD, an HDAC inhibitor, attenuates aortic remodeling in rats with TAC-induced pressure overload rats and may serve as a potential therapeutic target of antiaortic remodeling in pressure overload-induced hypertension-related diseases.
American Psychological Association (APA)
Jung, Hanna& Lee, Eunjo& Kim, Inkyeom& Kim, Gun Jik. 2020. Histone Deacetylase Inhibition Attenuates Aortic Remodeling in Rats under Pressure Overload. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134122
Modern Language Association (MLA)
Jung, Hanna…[et al.]. Histone Deacetylase Inhibition Attenuates Aortic Remodeling in Rats under Pressure Overload. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1134122
American Medical Association (AMA)
Jung, Hanna& Lee, Eunjo& Kim, Inkyeom& Kim, Gun Jik. Histone Deacetylase Inhibition Attenuates Aortic Remodeling in Rats under Pressure Overload. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134122