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The Role of Adenosine A2A Receptor, CYP450s, and PPARs in the Regulation of Vascular Tone
Joint Authors
Khayat, Maan T.
Nayeem, Mohammed A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Adenosine is an endogenous mediator involved in a myriad of physiologic functions, including vascular tone regulation.
It is also implicated in some pathologic conditions.
Four distinct receptor subtypes mediate the effects of adenosine, such as its role in the regulation of the vascular tone.
Vascular tone regulation is a complex and continuous process which involves many mechanisms and mediators that are not fully disclosed.
The vascular endothelium plays a pivotal role in regulating blood flow to and from all body organs.
Also, the vascular endothelium is not merely a physical barrier; it is a complex tissue with numerous functions.
Among adenosine receptors, A2A receptor subtype (A2AAR) stands out as the primary receptor responsible for the vasodilatory effects of adenosine.
This review focuses on important effectors of the vascular endothelium, including adenosine, adenosine receptors, EETs (epoxyeicosatrienoic acids), HETEs (hydroxyeicosatetraenoic acids), PPARs (peroxisome proliferator-activated receptors), and KATP channels.
Given the impact of vascular tone regulation in cardiovascular physiology and pathophysiology, better understanding of the mechanisms affecting it could have a significant potential for developing therapeutic agents for cardiovascular diseases.
American Psychological Association (APA)
Khayat, Maan T.& Nayeem, Mohammed A.. 2017. The Role of Adenosine A2A Receptor, CYP450s, and PPARs in the Regulation of Vascular Tone. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1134134
Modern Language Association (MLA)
Khayat, Maan T.& Nayeem, Mohammed A.. The Role of Adenosine A2A Receptor, CYP450s, and PPARs in the Regulation of Vascular Tone. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1134134
American Medical Association (AMA)
Khayat, Maan T.& Nayeem, Mohammed A.. The Role of Adenosine A2A Receptor, CYP450s, and PPARs in the Regulation of Vascular Tone. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1134134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134134