PD-L1 Expression in TNBC: A Predictive Biomarker of Response to Neoadjuvant Chemotherapy?
Joint Authors
d’Amati, Giulia
Cerbelli, Bruna
Marchetti, Paolo
Pernazza, Angelina
Botticelli, Andrea
Fortunato, Lucio
Monti, Massimo
Sciattella, Paolo
Campagna, Domenico
Mazzuca, Federica
Mauri, Maria
Naso, Giuseppe
Costarelli, Leopoldo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Triple negative breast cancer (TNBC) has an aggressive clinical behaviour, with a poorer prognosis compared to other subtypes.
Recently, tumor-infiltrating lymphocytes (TILs) have been proposed as a predictive biomarker for a better clinical outcome and pathological response (pR) after neoadjuvant chemotherapy (NACT) in TNBC.
These data confirm the role of the immune system in the neoplastic progression and in the response to therapy.
We performed a retrospective analysis of 54 pre-NACT biopsies of TNBC and compared both the percentage of stromal TILs and the degree of PD-L1 expression with the extent of pR to standard NACT.
A pathological complete response (pCR) was achieved in 35% of cases.
Univariate analysis showed (i) a significant association between PD-L1 expression in ≥25% of neoplastic cells and the achievement of a pCR (p=0.024); (ii) a significantly higher frequency of pCR in cases showing ≥50% stromal TILs (p<0.001).
However in the multivariate analysis only PD-L1 expression on tumor cells remained significantly associated with pCR (OR = 1,13; 95% CI 1,01–1,27), suggesting that the expression of this biomarker could be associated with a subpopulation of TNBC more likely to respond to chemotherapy.
These data need to be confirmed by larger studies.
American Psychological Association (APA)
Cerbelli, Bruna& Pernazza, Angelina& Botticelli, Andrea& Fortunato, Lucio& Monti, Massimo& Sciattella, Paolo…[et al.]. 2017. PD-L1 Expression in TNBC: A Predictive Biomarker of Response to Neoadjuvant Chemotherapy?. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134164
Modern Language Association (MLA)
Cerbelli, Bruna…[et al.]. PD-L1 Expression in TNBC: A Predictive Biomarker of Response to Neoadjuvant Chemotherapy?. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1134164
American Medical Association (AMA)
Cerbelli, Bruna& Pernazza, Angelina& Botticelli, Andrea& Fortunato, Lucio& Monti, Massimo& Sciattella, Paolo…[et al.]. PD-L1 Expression in TNBC: A Predictive Biomarker of Response to Neoadjuvant Chemotherapy?. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134164