Interaction of miR-181b and IFNA1 Polymorphisms on the Risk of Systemic Lupus Erythematosus
Joint Authors
He, Yong-Ling
Yang, Jun
Zeng, Zhi-Neng
Shi, Xiang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
A previous work has discovered that chromosome 1q32 locus linked to the risk of systemic lupus erythematosus (SLE) and miR-181b located on the susceptibility site with downregulation inversely correlating to its target molecular interferon alpha 1 (IFNA1).
The purpose of this study was to investigate the association of miR-181b and IFNA1 polymorphisms with IS risk.
Methods.
The miR-181b rs322931, IFNA1 rs1332190, and rs10811543 were genotyped using a Multiplex SNaPshot assay.
miR-181b expression levels in plasma of SLE patients and controls were analyzed using quantitative PCR.
Results.
The rs322931 CT, CT/TT, and T allele exerted an increased trend of SLE risk (CT vs.
CC: adjusted OR=1.71, 95% CI 1.16-2.50, P=0.01; CT/TT vs.
CC: adjusted OR=1.45, 95% CI 1.08-1.95, P=0.01; T vs.
C: adjusted OR=1.38, 95% CI 1.07-1.79, P=0.01).
Combined genotypes of the rs322931 CT/TT+rs1332190 TT and the rs322931 CC+rs10811543 AG/AA also revealed an increased risk of SLE.
Gene-gene interaction analysis showed that a three-locus model consisting of rs322931, rs1332190, and rs10811543 attributed an increased risk of SLE.
Further genotype-phenotype analysis revealed that rs322931 CT/TT carriers displayed lower levels of miR-181b.
Conclusions.
These findings indicate that the miR-181b rs322931 may be singly and jointly responsible for the etiology of SLE by altering miR-181b expression.
American Psychological Association (APA)
He, Yong-Ling& Yang, Jun& Zeng, Zhi-Neng& Shi, Xiang. 2020. Interaction of miR-181b and IFNA1 Polymorphisms on the Risk of Systemic Lupus Erythematosus. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1134181
Modern Language Association (MLA)
He, Yong-Ling…[et al.]. Interaction of miR-181b and IFNA1 Polymorphisms on the Risk of Systemic Lupus Erythematosus. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1134181
American Medical Association (AMA)
He, Yong-Ling& Yang, Jun& Zeng, Zhi-Neng& Shi, Xiang. Interaction of miR-181b and IFNA1 Polymorphisms on the Risk of Systemic Lupus Erythematosus. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1134181
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134181