Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature
Joint Authors
Newey, C. R.
Hantus, S.
George, P.
Mullaguri, Naresh
Punia, Vineet
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Acute symptomatic seizures are frequent in the critically ill patient and can be difficult to treat.
The novel anticonvulsant perampanel may be effective in the treatment of status epilepticus considering its mechanism of action of being an AMPA antagonist.
We present four cases of super refractory status epilepticus treated with high dose perampanel.
Method.
Case report.
Cases.
Four patients were treated with perampanel for their refractory status epilepticus.
One patient had new onset refractory status epilepticus of unknown etiology.
Three other patients had status epilepticus as a result of their cardiac arrest.
Two of the cardiac arrest patients had myoclonus.
In all patients, the additional of perampanel resulted in a reduction of seizure burden without affecting hemodynamics or hepatic or renal function.
Conclusion.
Perampanel may be effective in the treatment of super-refractory status epilepticus of varying etiologies.
A larger, prospective study is needed to further assess this therapy.
American Psychological Association (APA)
Newey, C. R.& Mullaguri, Naresh& Hantus, S.& Punia, Vineet& George, P.. 2019. Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature. Case Reports in Critical Care،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1134192
Modern Language Association (MLA)
George, P.…[et al.]. Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature. Case Reports in Critical Care No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1134192
American Medical Association (AMA)
Newey, C. R.& Mullaguri, Naresh& Hantus, S.& Punia, Vineet& George, P.. Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature. Case Reports in Critical Care. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1134192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134192