Possible Estrogen Dependency in the Pathogenesis of Branchial Cleft Cysts
Joint Authors
Anagnostopoulos, Ioannis
Doll, Christian
Raguse, Jan-Dirk
Jöhrens, Korinna
Heiland, Max
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Even though branchial cleft cysts are currently accepted as a congenital anomaly, there is often a long delay until clinical presentation; branchial cleft cysts classically appear in the second to fourth decade of life.
Our observation of their occurrence in three pregnant women encouraged us to contemplate a possible hormonal influence.
Methods.
Immunohistological analysis was performed for the evaluation of the estrogen receptor alpha (ERα) in paraffin-embedded tissue specimens of 16 patients with a diagnosis of branchial cleft cyst, with three of them being pregnant.
Results.
Expression of ERα was detected within epithelial cells only in branchial cleft cysts in pregnant females; moreover, higher growth fractions (Ki-67/Mib1) were found.
Conclusion.
The fact that the estrogen receptor was expressed only in pregnant women, in contrast to 13 investigated cases, may suggest that the high level of estrogen in pregnancy is a possible explanation for the spontaneous growth of branchial cleft cysts.
American Psychological Association (APA)
Raguse, Jan-Dirk& Anagnostopoulos, Ioannis& Doll, Christian& Heiland, Max& Jöhrens, Korinna. 2017. Possible Estrogen Dependency in the Pathogenesis of Branchial Cleft Cysts. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1134200
Modern Language Association (MLA)
Raguse, Jan-Dirk…[et al.]. Possible Estrogen Dependency in the Pathogenesis of Branchial Cleft Cysts. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1134200
American Medical Association (AMA)
Raguse, Jan-Dirk& Anagnostopoulos, Ioannis& Doll, Christian& Heiland, Max& Jöhrens, Korinna. Possible Estrogen Dependency in the Pathogenesis of Branchial Cleft Cysts. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1134200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134200