A Simulation Study on the Pacing and Driving of the Biological Pacemaker
Joint Authors
Zhang, Lei
Wang, Yong
Zhang, Yue
Wang, Kuanquan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The research on the biological pacemaker has been very active in recent years.
And turning nonautomatic ventricular cells into pacemaking cells is believed to hold the key to making a biological pacemaker.
In the study, the inward-rectifier K+ current (IK1) is depressed to induce the automaticity of the ventricular myocyte, and then, the effects of the other membrane ion currents on the automaticity are analyzed.
It is discovered that the L-type calcium current (ICaL) plays a major part in the rapid depolarization of the action potential (AP).
A small enough ICaL would lead to the failure of the automaticity of the ventricular myocyte.
Meanwhile, the background sodium current (IbNa), the background calcium current (IbCa), and the Na+/Ca2+ exchanger current (INaCa) contribute significantly to the slow depolarization, indicating that these currents are the main supplementary power of the pacing induced by depressing IK1, while in the 2D simulation, we find that the weak electrical coupling plays a more important role in the driving of a biological pacemaker.
American Psychological Association (APA)
Zhang, Yue& Zhang, Lei& Wang, Yong& Wang, Kuanquan. 2020. A Simulation Study on the Pacing and Driving of the Biological Pacemaker. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134210
Modern Language Association (MLA)
Zhang, Yue…[et al.]. A Simulation Study on the Pacing and Driving of the Biological Pacemaker. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1134210
American Medical Association (AMA)
Zhang, Yue& Zhang, Lei& Wang, Yong& Wang, Kuanquan. A Simulation Study on the Pacing and Driving of the Biological Pacemaker. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134210