Anti-Inflammatory Effect of Dialyzable Leukocyte Extract in Autoimmune Prostatitis: Evaluation in Animal Model
Joint Authors
Pérez-Ishiwara, David Guillermo
Pérez-Alvarado, Carlos
Reyes, Miguel
García, Mario
Pérez, Elizabeth
Pérez de la Mora, Carlos
Sánchez Monroy, Virginia
Gomez, Consuelo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To evaluate the anti-inflammatory properties of Dialyzable Leukocyte Extract (DLE) in a murine model of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
Methods.
Histopathological characterization, prostatein Enzyme-Linked Immunosorbent Assay, and immunohistochemical analysis for CD45, TNF-α, IFN-γ, IL-6, IL-17, and IL-4 molecules were done in prostatic Wistar rats treated with DLE, placebo, or Dexamethasone.
Results.
Histopathological analysis of animals induced to prostatitis showed inflammatory infiltrate, mainly constituted by leucocytes and mast cells as well as Benign Prostatic Hyperplasia.
Serum prostatein concentrations were 14 times higher than those displayed by healthy animals.
After DLE and Dexamethasone treatments, the inflammatory infiltrate decreased; the tissue morphology was similar to that of a normal prostate, and the prostatein decreased to the basal levels of healthy animals.
DLE treatment produced a decreased expression of the cell surface marker CD45 and the proinflammatory cytokines TNF-α, IFN-γ, IL-6, and IL-17.
On the other hand, the expression of anti-inflammatory cytokine IL-4 increased in both the Dexamethasone and DLE groups.
Conclusion.
DLE is able to modulate the inflammatory response in Experimental Autoimmune Prostatitis (EAP).
American Psychological Association (APA)
Pérez-Alvarado, Carlos& Gomez, Consuelo& Reyes, Miguel& García, Mario& Pérez, Elizabeth& Pérez de la Mora, Carlos…[et al.]. 2017. Anti-Inflammatory Effect of Dialyzable Leukocyte Extract in Autoimmune Prostatitis: Evaluation in Animal Model. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134229
Modern Language Association (MLA)
Pérez-Alvarado, Carlos…[et al.]. Anti-Inflammatory Effect of Dialyzable Leukocyte Extract in Autoimmune Prostatitis: Evaluation in Animal Model. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134229
American Medical Association (AMA)
Pérez-Alvarado, Carlos& Gomez, Consuelo& Reyes, Miguel& García, Mario& Pérez, Elizabeth& Pérez de la Mora, Carlos…[et al.]. Anti-Inflammatory Effect of Dialyzable Leukocyte Extract in Autoimmune Prostatitis: Evaluation in Animal Model. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134229