The ceRNA Network Has Potential Prognostic Value in Clear Cell Renal Cell Carcinoma: A Study Based on TCGA Database

Abstract EN

Clear cell renal cell carcinoma (ccRCC) is a very common cancer in urology.

Many evidences suggest that complex changed pathways take a nonnegligible part in the occurrence and development of ccRCC.

Nevertheless, the underlying mechanism is not clear.

In this study, the expression data between ccRCC and normal tissue samples in TCGA database were compared to distinguish differentially expressed genes (DEGs: mRNAs, miRNAs, and lncRNAs).

Afterwards, we used GO enrichment and KEGG pathway enrichment analyses to explore the functions of these DEGs.

We also found the correlation between three RNAs and created a competing endogenous RNA (ceRNA) network.

Moreover, we used univariate Cox regression analysis to select DEGs that are connected with overall survival (OS) of ccRCC patients.

We found 1652 mRNAs, 1534 lncRNAs, and 173 miRNAs that were distinguished in ccRCC compared with normal tissues.

According to GO analysis, the maladjusted mRNAs are mainly concentrated in immune cell activation and kidney development, while according to KEGG, they are mainly concentrated in pathways related to cancer.

A total of 5 mRNAs, 1 miRNA, and 4 lncRNAs were connected with patients’ OS.

In this article, a network of lncRNA-miRNA-mRNA was established; it is expected to be able to indicate possible molecular mechanisms for initial of ccRCC and provide a new viewpoint for diagnosis of ccRCC.