Integrating miRNA and mRNA Expression Profiling Uncovers miRNAs Underlying Fat Deposition in Sheep
Joint Authors
Chen, Yulin
Zhou, Guangxian
Wang, Xiaolong
Yuan, Chao
Kang, Danju
Xu, Xiaochun
Zhou, Jiping
Geng, Rongqing
Yang, Yuxin
Yang, Zhaoxia
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are endogenous, noncoding RNAs that regulate various biological processes including adipogenesis and fat metabolism.
Here, we adopted a deep sequencing approach to determine the identity and abundance of miRNAs involved in fat deposition in adipose tissues from fat-tailed (Kazakhstan sheep, KS) and thin-tailed (Tibetan sheep, TS) sheep breeds.
By comparing HiSeq data of these two breeds, 539 miRNAs were shared in both breeds, whereas 179 and 97 miRNAs were uniquely expressed in KS and TS, respectively.
We also identified 35 miRNAs that are considered to be putative novel miRNAs.
The integration of miRNA-mRNA analysis revealed that miRNA-associated targets were mainly involved in the gene ontology (GO) biological processes concerning cellular process and metabolic process, and miRNAs play critical roles in fat deposition through their ability to regulate fundamental pathways.
These pathways included the MAPK signaling pathway, FoxO and Wnt signaling pathway, and focal adhesion.
Taken together, our results define miRNA expression signatures that may contribute to fat deposition and lipid metabolism in sheep.
American Psychological Association (APA)
Zhou, Guangxian& Wang, Xiaolong& Yuan, Chao& Kang, Danju& Xu, Xiaochun& Zhou, Jiping…[et al.]. 2017. Integrating miRNA and mRNA Expression Profiling Uncovers miRNAs Underlying Fat Deposition in Sheep. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134289
Modern Language Association (MLA)
Zhou, Guangxian…[et al.]. Integrating miRNA and mRNA Expression Profiling Uncovers miRNAs Underlying Fat Deposition in Sheep. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1134289
American Medical Association (AMA)
Zhou, Guangxian& Wang, Xiaolong& Yuan, Chao& Kang, Danju& Xu, Xiaochun& Zhou, Jiping…[et al.]. Integrating miRNA and mRNA Expression Profiling Uncovers miRNAs Underlying Fat Deposition in Sheep. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134289