Identification of Circulating MicroRNAs as a Promising Diagnostic Biomarker for Cervical Intraepithelial Neoplasia and Early Cancer: A Meta-Analysis
Joint Authors
Jiang, Yao
Li, Yiqin
Guo, Yongcan
Tao, Hualin
Hu, Zuohong
Zuo, Zhihua
Pu, Fei
Wang, Biqiong
Tang, Yan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Cervical cancer (CC) is one of the most common female malignant tumors.
And cervical intraepithelial neoplasia (CIN) is the precancerous lesion of CC, which can progress to invasive CC.
MicroRNAs (miRNAs) have been found to be potential diagnostic biomarkers for CIN or CC.
However, recently, the lack of sufficient studies about the diagnostic value of miRNAs for CIN made it challenging to separately investigate the diagnostic efficacy of miRNAs for CIN.
Likewise, the conclusions among those studies were discordant.
Therefore, we conducted this meta-analysis, aimed at evaluating the diagnostic efficacy of miRNAs for CIN and CC patients.
Methods.
Literature search was performed in PubMed, Embase, and Web of Science databases.
Pooled sensitivity, specificity, and other diagnostic parameters were calculated through Stata 14.0 software.
Furthermore, subgroup analyses and metaregression analysis were conducted to explore the main sources of heterogeneity.
Results.
Ten articles covering 50 studies were eligible, which included 5,908 patients and 4,819 healthy individuals.
The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were 0.81 (95% CI, 0.77-0.85), 0.86 (95% CI, 0.83-0.89), 5.9 (95% CI, 4.5-7.7), 0.22 (95% CI, 0.17-0.28), 27 (95% CI, 17-44), and 0.91 (95% CI, 0.88-0.93), respectively.
Additionally, the ethnicity and internal reference were the main sources of heterogeneity.
Conclusions.
Circulating miRNAs can be a promising noninvasive diagnostic biomarker for CIN and early CC, especially miR-9 and miR-205, which need to be verified by large-scale studies.
American Psychological Association (APA)
Jiang, Yao& Hu, Zuohong& Zuo, Zhihua& Li, Yiqin& Pu, Fei& Wang, Biqiong…[et al.]. 2020. Identification of Circulating MicroRNAs as a Promising Diagnostic Biomarker for Cervical Intraepithelial Neoplasia and Early Cancer: A Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1134330
Modern Language Association (MLA)
Jiang, Yao…[et al.]. Identification of Circulating MicroRNAs as a Promising Diagnostic Biomarker for Cervical Intraepithelial Neoplasia and Early Cancer: A Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1134330
American Medical Association (AMA)
Jiang, Yao& Hu, Zuohong& Zuo, Zhihua& Li, Yiqin& Pu, Fei& Wang, Biqiong…[et al.]. Identification of Circulating MicroRNAs as a Promising Diagnostic Biomarker for Cervical Intraepithelial Neoplasia and Early Cancer: A Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1134330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134330