Comprehensive Analysis of Differentially Expressed Circular RNAs in Patients with Senile Osteoporotic Vertebral Compression Fracture
Joint Authors
Yao, Xiaocong
Liu, Minbo
Jin, Fang
Zhu, Zhongxin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aim.
Circular RNAs (circRNAs) have been found to contribute to the regulation of many diseases and are abundantly expressed in various organisms.
The present study is aimed at systematically characterizing the circRNA expression profiles in patients with senile osteoporotic vertebral compression fracture (OVCF) and predicting the potential functions of the regulatory networks correlated with these differentially expressed circRNAs.
Methods.
The circRNA expression profile in patients with senile OVCF was explored by using RNA sequencing.
The prediction of the enriched signaling pathways and circRNA-miRNA networks was conducted by bioinformatics analysis.
Real-time quantitative PCR was used to validate the selected differentially expressed circRNAs from 20 patients with senile OVCF relative to 20 matched healthy controls.
Results.
A total of 884 differentially expressed circRNAs were identified, of which 554 were upregulated and 330 were downregulated.
The top 15 signaling pathways associated with these differentially expressed circRNAs were predicted.
The result of qRT-PCR of the selected circRNAs was consistent with RNA sequencing.
Conclusions.
CircRNAs are differentially expressed in patients with senile OVCF, which might contribute to the pathophysiological mechanism of senile osteoporosis.
American Psychological Association (APA)
Yao, Xiaocong& Liu, Minbo& Jin, Fang& Zhu, Zhongxin. 2020. Comprehensive Analysis of Differentially Expressed Circular RNAs in Patients with Senile Osteoporotic Vertebral Compression Fracture. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134333
Modern Language Association (MLA)
Yao, Xiaocong…[et al.]. Comprehensive Analysis of Differentially Expressed Circular RNAs in Patients with Senile Osteoporotic Vertebral Compression Fracture. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1134333
American Medical Association (AMA)
Yao, Xiaocong& Liu, Minbo& Jin, Fang& Zhu, Zhongxin. Comprehensive Analysis of Differentially Expressed Circular RNAs in Patients with Senile Osteoporotic Vertebral Compression Fracture. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134333