MYC Gene Rearrangements Are Closely Associated with Poor Survival of Diffuse Large B Cell Lymphoma with Hepatitis B Virus Infection
Joint Authors
Liu, Zhihe
Li, Siyun
Guo, Wei
Wang, Yinping
Wang, Ming
Bai, Ou
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to identify clinical adverse prognostic factors affecting overall survival (OS) of diffuse large B cell (DLBCL) patients with hepatitis B virus (HBV) infection.
In this study, 30 DLBCL patients with HBV infection and 51 DLBCL patients with HBV-free were reviewed retrospectively.
As of July 2016, the median follow-up period was 26.4 months (3.0~65.0 months).
The median OS of patients in HBV infection group was 38.6 months, while that of patients in HBV-free group was not reached (P=0.042); the median progression-free survival (PFS) of patients in HBV infection group was worse than that in HBV-free group, 18.5 months and 38.5 months (P=0.118), respectively.
The rate of MYC and BCL2 gene rearrangements in HBV infection group was significantly higher than that in HBV-free group, 20.0% versus 3.9% (P=0.019) and 23.3% versus 5.9% (P=0.021), respectively.
Multivariable analysis indicated that IPI (P=0.002), chemotherapy regimens (P=0.017), and MYC gene rearrangements (P=0.004) were independent adverse prognostic factors for all DLBCL patients in this study.
Results demonstrated that the poor survival of DLBCL patients with HBV infection was closely involved in chemotherapy regimens, IPI, and MYC gene rearrangements.
American Psychological Association (APA)
Liu, Zhihe& Li, Siyun& Guo, Wei& Wang, Yinping& Wang, Ming& Bai, Ou. 2017. MYC Gene Rearrangements Are Closely Associated with Poor Survival of Diffuse Large B Cell Lymphoma with Hepatitis B Virus Infection. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134371
Modern Language Association (MLA)
Liu, Zhihe…[et al.]. MYC Gene Rearrangements Are Closely Associated with Poor Survival of Diffuse Large B Cell Lymphoma with Hepatitis B Virus Infection. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1134371
American Medical Association (AMA)
Liu, Zhihe& Li, Siyun& Guo, Wei& Wang, Yinping& Wang, Ming& Bai, Ou. MYC Gene Rearrangements Are Closely Associated with Poor Survival of Diffuse Large B Cell Lymphoma with Hepatitis B Virus Infection. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134371