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The Neuroprotective Effects of Muscle-Derived Stem Cells via Brain-Derived Neurotrophic Factor in Spinal Cord Injury Model
Joint Authors
Wang, Yansong
Yuan, Yajiang
Han, Donghe
Chen, Shurui
Fang, Shiqiang
Liu, Shiqiong
Jin, Meihua
Guo, Zhanpeng
Liu, Chang
Mei, Xifan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Muscle-derived stem cells (MDSCs) possess multipotent differentiation and self-renewal capacities; however, the effects and mechanism in neuron injury remain unclear.
The aim of this study was to investigate the effects of MDSCs on neuron secondary injury, oxidative stress-induced apoptosis.
An in vivo study showed the Basso, Beattie, and Bresnahan (BBB) score and number of neurons significantly increased after MDSCs’ transplantation in spinal cord injury (SCI) rats.
An in vitro study demonstrated that MDSCs attenuated neuron apoptosis, and the expression of antioxidants was upregulated as well as the ratio of Bcl-2 and Bax in the MNT (MDSCs cocultured with injured neurons) group compared with the NT (injured neurons) group.
Both LC3II/LC3I and β-catenin were enhanced in the MNT group, while XAV939 (a β-catenin inhibitor) decreased the expression of nuclear erythroid-related factor 2 (Nrf2) and LC3II/LC3I.
Moreover, MDSCs became NSE- (neuron-specific enolase-) positive neuron-like cells with brain-derived neurotrophic factor (BDNF) treatment.
The correlation analysis indicated that there was a significant relation between the level of BDNF and neuron injury.
These findings suggest that MDSCs may protect the spinal cord from injury by inhibiting apoptosis and replacing injured neurons, and the increased BDNF and β-catenin could contribute to MDSCs’ effects.
American Psychological Association (APA)
Han, Donghe& Chen, Shurui& Fang, Shiqiang& Liu, Shiqiong& Jin, Meihua& Guo, Zhanpeng…[et al.]. 2017. The Neuroprotective Effects of Muscle-Derived Stem Cells via Brain-Derived Neurotrophic Factor in Spinal Cord Injury Model. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134393
Modern Language Association (MLA)
Han, Donghe…[et al.]. The Neuroprotective Effects of Muscle-Derived Stem Cells via Brain-Derived Neurotrophic Factor in Spinal Cord Injury Model. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1134393
American Medical Association (AMA)
Han, Donghe& Chen, Shurui& Fang, Shiqiang& Liu, Shiqiong& Jin, Meihua& Guo, Zhanpeng…[et al.]. The Neuroprotective Effects of Muscle-Derived Stem Cells via Brain-Derived Neurotrophic Factor in Spinal Cord Injury Model. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134393