The Combination of the Tumor Markers Suggests the Histological Diagnosis of Lung Cancer
Joint Authors
Liu, Linjie
Teng, Jinlong
Zhang, Lijun
Cong, Peishan
Yao, Yuan
Sun, Guirong
Liu, Zhijun
Yu, Teng
Liu, Mingjun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Tumor markers are beneficial for the diagnosis and therapy monitoring of lung cancer.
However, the value of tumor markers in lung cancer histological diagnosis is unknown.
In this study, we analyzed the serum levels of six tumor markers (CEA, CYFRA21-1, SCC, NSE, ProGRP, and CA125) in 2097 suspected patients with lung cancer and determined whether the combination of the tumor markers was useful for histological diagnosis of lung cancer.
We found that CYFRA21-1 was the most sensitive marker in NSCLC.
ProGRP showed a better clinical performance than that of NSE in discriminating between SCLC and NSCLC.
The serum level of CYFRA21-1 or SCC was significantly higher in squamous carcinoma (p<0.05), and the levels of ProGRP and NSE were significantly higher in SCLC (p<0.05).
According to the criteria established, SCLC and NSCLC were discriminated with sensitivity of 87.12 and 62.63% and specificity of 64.61 and 99.5%, respectively.
The sensitivity and specificity in the differentiation of adenocarcinoma and squamous carcinoma were 68.1 and 81.63% and 70.73 and 65.93%, with NPV of 46.03 and 68.97% and PPV of 85.82 and 79.47%, respectively.
Our results suggested the combination of six tumor markers could discriminate the histological types of lung cancer.
American Psychological Association (APA)
Liu, Linjie& Teng, Jinlong& Zhang, Lijun& Cong, Peishan& Yao, Yuan& Sun, Guirong…[et al.]. 2017. The Combination of the Tumor Markers Suggests the Histological Diagnosis of Lung Cancer. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134407
Modern Language Association (MLA)
Liu, Linjie…[et al.]. The Combination of the Tumor Markers Suggests the Histological Diagnosis of Lung Cancer. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1134407
American Medical Association (AMA)
Liu, Linjie& Teng, Jinlong& Zhang, Lijun& Cong, Peishan& Yao, Yuan& Sun, Guirong…[et al.]. The Combination of the Tumor Markers Suggests the Histological Diagnosis of Lung Cancer. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134407