Protein Phosphorylation in Serine Residues Correlates with Progression from Precancerous Lesions to Cervical Cancer in Mexican Patients
Joint Authors
Reséndiz-Albor, Aldo Arturo
Padilla-Mendoza, Juan Ramón
Contis-Montes de Oca, Arturo
López-Casamichana, Mavil
Bolaños, Jeni
Quintas-Granados, Laura Itzel
Reyes-Hernández, Octavio Daniel
Fragozo-Sandoval, Fabiola
Arellano-Gutiérrez, Claudia Vanessa
López-Reyes, Israel
Rodríguez, Mario A.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Protein phosphorylation is a posttranslational modification that is essential for normal cellular processes; however, abnormal phosphorylation is one of the prime causes for alteration of many structural, functional, and regulatory proteins in disease conditions.
In cancer, changes in the states of protein phosphorylation in tyrosine residues have been more studied than phosphorylation in threonine or serine residues, which also undergo alterations with greater predominance.
In general, serine phosphorylation leads to the formation of multimolecular signaling complexes that regulate diverse biological processes, but in pathological conditions such as tumorigenesis, anomalous phosphorylation may result in the deregulation of some signaling pathways.
Cervical cancer (CC), the main neoplasm associated with human papillomavirus (HPV) infection, is the fourth most frequent cancer worldwide.
Persistent infection of the cervix with high-risk human papillomaviruses produces precancerous lesions starting with low-grade squamous intraepithelial lesions (LSIL), progressing to high-grade squamous intraepithelial lesions (HSIL) until CC is generated.
Here, we compared the proteomic profile of phosphorylated proteins in serine residues from healthy, LSIL, HSIL, and CC samples.
Our data show an increase in the number of phosphorylated proteins in serine residues as the grade of injury rises.
These results provide a support for future studies focused on phosphorylated proteins and their possible correlation with the progression of cervical lesions.
American Psychological Association (APA)
Padilla-Mendoza, Juan Ramón& Contis-Montes de Oca, Arturo& Rodríguez, Mario A.& López-Casamichana, Mavil& Bolaños, Jeni& Quintas-Granados, Laura Itzel…[et al.]. 2020. Protein Phosphorylation in Serine Residues Correlates with Progression from Precancerous Lesions to Cervical Cancer in Mexican Patients. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1134419
Modern Language Association (MLA)
Padilla-Mendoza, Juan Ramón…[et al.]. Protein Phosphorylation in Serine Residues Correlates with Progression from Precancerous Lesions to Cervical Cancer in Mexican Patients. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1134419
American Medical Association (AMA)
Padilla-Mendoza, Juan Ramón& Contis-Montes de Oca, Arturo& Rodríguez, Mario A.& López-Casamichana, Mavil& Bolaños, Jeni& Quintas-Granados, Laura Itzel…[et al.]. Protein Phosphorylation in Serine Residues Correlates with Progression from Precancerous Lesions to Cervical Cancer in Mexican Patients. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1134419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134419