α-MSH Influences the Excitability of Feeding-Related Neurons in the Hypothalamus and Dorsal Vagal Complex of Rats
Joint Authors
Guan, Hong-Zai
Dong, Jing
Jiang, Zheng-Yao
Chen, Xi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alpha-melanocyte-stimulating hormone (α-MSH) is processed from proopiomelanocortin (POMC) and acts on the melanocortin receptors, MC3 and MC4.
α-MSH plays a key role in energy homeostasis.
In the present study, to shed light on the mechanisms by which α-MSH exerts its anorectic effects, extracellular neuronal activity was recorded in the hypothalamus and the dorsal vagal complex (DVC) of anesthetized rats.
We examined the impact of α-MSH on glucose-sensing neurons and gastric distension (GD) sensitive neurons.
In the lateral hypothalamus (LHA), α-MSH inhibited 75.0% of the glucose-inhibited (GI) neurons.
In the ventromedial nucleus (VMN), most glucose-sensitive neurons were glucose-excited (GE) neurons, which were mainly activated by α-MSH.
In the paraventricular nucleus (PVN), α-MSH suppressed the majority of GI neurons and excited most GE neurons.
In the DVC, among the 20 GI neurons examined for a response to α-MSH, 1 was activated, 16 were depressed, and 3 failed to respond.
Nineteen of 24 GE neurons were activated by α-MSH administration.
Additionally, among the 42 DVC neurons examined for responses to GD, 23 were excited (GD-EXC) and 19 were inhibited (GD-INH).
Fifteen of 20 GD-EXC neurons were excited, whereas 11 out of 14 GD-INH neurons were suppressed by α-MSH.
All these responses were abolished by pretreatment with the MC3/4R antagonist, SHU9119.
In conclusion, the activity of glucose-sensitive neurons and GD-sensitive neurons in the hypothalamus and DVC can be modulated by α-MSH.
American Psychological Association (APA)
Guan, Hong-Zai& Dong, Jing& Jiang, Zheng-Yao& Chen, Xi. 2017. α-MSH Influences the Excitability of Feeding-Related Neurons in the Hypothalamus and Dorsal Vagal Complex of Rats. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134451
Modern Language Association (MLA)
Guan, Hong-Zai…[et al.]. α-MSH Influences the Excitability of Feeding-Related Neurons in the Hypothalamus and Dorsal Vagal Complex of Rats. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1134451
American Medical Association (AMA)
Guan, Hong-Zai& Dong, Jing& Jiang, Zheng-Yao& Chen, Xi. α-MSH Influences the Excitability of Feeding-Related Neurons in the Hypothalamus and Dorsal Vagal Complex of Rats. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134451