Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™
Joint Authors
Tangen, Jon-Magnus
Holien, Toril
Mirlashari, Mohammad Reza
Misund, Kristine
Hetland, Geir
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Agaricus blazei Murill is an edible mushroom of the Basidiomycetes family, which has been found to contain a number of compounds with antitumor properties, such as proteoglycans and ergosterol.
In the present investigation, we show that the commercial mushroom product Andosan, which contains 82.4% Agaricus blazei Murill, together with medicinal mushrooms Hericium erinaceus (14.7%) and Grifola frondosa (2.9%), has a cytotoxic effect on primary myeloma cells, other myeloma cell lines, and leukemia cell lines in vitro.
Although the exact content and hence the mechanisms of action of the Andosan extract are unknown, we have found in this investigation indications of cell cycle arrest when myeloma cell lines are cultivated with Andosan.
This may be one of the possible explanations for the cytotoxic effects of Andosan.
American Psychological Association (APA)
Tangen, Jon-Magnus& Holien, Toril& Mirlashari, Mohammad Reza& Misund, Kristine& Hetland, Geir. 2017. Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134493
Modern Language Association (MLA)
Tangen, Jon-Magnus…[et al.]. Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1134493
American Medical Association (AMA)
Tangen, Jon-Magnus& Holien, Toril& Mirlashari, Mohammad Reza& Misund, Kristine& Hetland, Geir. Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134493