Magnetic Resonance Elastography Shear Wave Velocity Correlates with Liver Fibrosis and Hepatic Venous Pressure Gradient in Adults with Advanced Liver Disease
Joint Authors
Kovacs, Joseph A.
Kottilil, Shyam
Meissner, Eric G.
Gharib, Ahmed M.
Han, Ma Ai Thanda
Kleiner, David E.
Zhao, Xiongce
McLaughlin, Mary
Matthews, Lindsay
Rizvi, Bisharah
Abd-Elmoniem, Khaled Z.
Sinkus, Ralph
Levy, Elliot
Koh, Christopher
Myers, Robert P.
Subramanian, G. Mani
Heller, Theo
Morse, Caryn G.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Portal hypertension, an elevation in the hepatic venous pressure gradient (HVPG), can be used to monitor disease progression and response to therapy in cirrhosis.
Since obtaining HVPG measurements is invasive, reliable noninvasive methods of assessing portal hypertension are needed.
Methods.
Noninvasive markers of fibrosis, including magnetic resonance elastography (MRE) shear wave velocity, were correlated with histologic fibrosis and HVPG measurements in hepatitis C (HCV) and/or HIV-infected patients with advanced liver disease enrolled in a clinical trial of treatment with simtuzumab, an anti-LOXL2 antibody.
Results.
This exploratory analysis includes 23 subjects: 9 with HCV monoinfection, 9 with HIV and HCV, and 5 with HIV and nonalcoholic steatohepatitis.
Median Ishak fibrosis score was 4 (range 1–6); 11 subjects (48%) had cirrhosis.
Median HVPG was 6 mmHg (range 3–16).
Liver stiffness measured by MRE correlated with HVPG (r=0.64, p=0.01), histologic fibrosis score (r=0.71, p=0.004), noninvasive fibrosis indices, including APRI (r=0.81, p<0.001), and soluble LOXL2 (r=0.82, p=0.001).
On stepwise multivariate regression analysis, MRE was the only variable independently associated with HVPG (R2=0.377, p=0.02).
Conclusions.
MRE of the liver correlated independently with HVPG.
MRE is a valid noninvasive measure of liver disease severity and may prove to be a useful tool for noninvasive portal hypertension assessment.
Trial Registration Number.
This trial is registered with NCT01707472.
American Psychological Association (APA)
Gharib, Ahmed M.& Han, Ma Ai Thanda& Meissner, Eric G.& Kleiner, David E.& Zhao, Xiongce& McLaughlin, Mary…[et al.]. 2017. Magnetic Resonance Elastography Shear Wave Velocity Correlates with Liver Fibrosis and Hepatic Venous Pressure Gradient in Adults with Advanced Liver Disease. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134500
Modern Language Association (MLA)
Gharib, Ahmed M.…[et al.]. Magnetic Resonance Elastography Shear Wave Velocity Correlates with Liver Fibrosis and Hepatic Venous Pressure Gradient in Adults with Advanced Liver Disease. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1134500
American Medical Association (AMA)
Gharib, Ahmed M.& Han, Ma Ai Thanda& Meissner, Eric G.& Kleiner, David E.& Zhao, Xiongce& McLaughlin, Mary…[et al.]. Magnetic Resonance Elastography Shear Wave Velocity Correlates with Liver Fibrosis and Hepatic Venous Pressure Gradient in Adults with Advanced Liver Disease. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134500