Multitarget Therapeutic Strategies for Alzheimer’s Disease: Review on Emerging Target Combinations
Joint Authors
Benchekroun, Mohamed
Gabr, Moustafa
Maramai, Samuele
Yahiaoui, Samir
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-03
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Neurodegenerative diseases represent nowadays one of the major health problems.
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not entirely clear what triggers this phenomenon and what allows its progression.
Nevertheless, it is accepted that neurodegeneration is a consequence of several detrimental processes, such as protein aggregation, oxidative stress, and neuroinflammation, finally resulting in the loss of neuronal functions.
Starting from these evidences, there has been a wide search for novel agents able to address more than a single event at the same time, the so-called multitarget-directed ligands (MTDLs).
These compounds originated from the combination of different pharmacophoric elements which endowed them with the ability to interfere with different enzymatic and/or receptor systems, or to exert neuroprotective effects by modulating proteins and metal homeostasis.
MTDLs have been the focus of the latest strategies to discover a new treatment for Alzheimer’s disease (AD), which is considered the most common form of dementia characterized by neurodegeneration and cognitive dysfunctions.
This review is aimed at collecting the latest and most interesting target combinations for the treatment of AD, with a detailed discussion on new agents with favorable in vitro properties and on optimized structures that have already been assessed in vivo in animal models of dementia.
American Psychological Association (APA)
Maramai, Samuele& Benchekroun, Mohamed& Gabr, Moustafa& Yahiaoui, Samir. 2020. Multitarget Therapeutic Strategies for Alzheimer’s Disease: Review on Emerging Target Combinations. BioMed Research International،Vol. 2020, no. 2020, pp.1-27.
https://search.emarefa.net/detail/BIM-1134505
Modern Language Association (MLA)
Maramai, Samuele…[et al.]. Multitarget Therapeutic Strategies for Alzheimer’s Disease: Review on Emerging Target Combinations. BioMed Research International No. 2020 (2020), pp.1-27.
https://search.emarefa.net/detail/BIM-1134505
American Medical Association (AMA)
Maramai, Samuele& Benchekroun, Mohamed& Gabr, Moustafa& Yahiaoui, Samir. Multitarget Therapeutic Strategies for Alzheimer’s Disease: Review on Emerging Target Combinations. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-27.
https://search.emarefa.net/detail/BIM-1134505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134505