Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits
Joint Authors
Martínez-Gómez, Margarita
Castelán, Francisco
Cuevas, Estela
Ortega, Arturo
Hernández-Aragón, Laura G.
García-Villamar, Verónica
Carrasco-Ruiz, María de los Ángeles
Nicolás-Toledo, Leticia
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We aimed to determine the role of estrogens in modulating the size of neuronal somata of paravaginal ganglia.
Rabbits were allocated into control (C), ovariectomized (OVX), and OVX treated with estradiol benzoate (OVX + EB) groups to evaluate the neuronal soma area; total serum estradiol (E2) and testosterone (T) levels; the percentage of immunoreactive (ir) neurons anti-aromatase, anti-estrogen receptor (ERα, ERβ) and anti-androgen receptor (AR); the intensity of the immunostaining anti-glial cell line-derived neurotrophic factor (GDNF) and the GDNF family receptor alpha type 1 (GFRα1); and the number of satellite glial cells (SGCs) per neuron.
There was a decrease in the neuronal soma size for the OVX group, which was associated with low T, high percentages of aromatase-ir and neuritic AR-ir neurons, and a strong immunostaining anti-GDNF and anti-GFRα1.
The decrease in the neuronal soma size was prevented by the EB treatment that increased the E2 without affecting the T levels.
Moreover, there was a high percentage of neuritic AR-ir neurons, a strong GDNF immunostaining in the SGC, and an increase in the SGCs per neuron.
Present findings show that estrogens modulate the soma size of neurons of the paravaginal ganglia, likely involving the participation of the SGC.
American Psychological Association (APA)
Hernández-Aragón, Laura G.& García-Villamar, Verónica& Carrasco-Ruiz, María de los Ángeles& Nicolás-Toledo, Leticia& Ortega, Arturo& Cuevas, Estela…[et al.]. 2017. Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134507
Modern Language Association (MLA)
Hernández-Aragón, Laura G.…[et al.]. Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1134507
American Medical Association (AMA)
Hernández-Aragón, Laura G.& García-Villamar, Verónica& Carrasco-Ruiz, María de los Ángeles& Nicolás-Toledo, Leticia& Ortega, Arturo& Cuevas, Estela…[et al.]. Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134507