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Ciprofloxacin Controlled-Solid Lipid Nanoparticles: Characterization, In Vitro Release, and Antibacterial Activity Assessment
Author
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective of this research was to formulate ciprofloxacin (CIP) in solid lipid nanoparticles (SLNs) in an attempt to develop a controlled drug delivery system.
An ultrasonic melt-emulsification method was used for preparing CIP-loaded SLNs.
Key findings included that SLNs were successfully produced with average particle sizes ranging from 165 to 320 nm and polydispersity index in the range of 0.18–0.33.
High entrapment efficiency values were reported in all formulations.
The atomic force scanning microscopic images showed spherical shape with the size range closer to those found by the particle size analyzer.
CIP release exhibited controlled-release behavior with various lipids.
Ciprofloxacin solid lipid nanoparticles formula containing stearic acid (CIPSTE) displayed the strongest burst effect and the most rapid release rate.
The release data revealed a better fit to the Higuchi diffusion model.
After storing the CIPSTE formula at room temperature for 120 days, no significant difference in particle size and zeta potential was found.
CIP-loaded SLNs exhibited superior antibacterial activity.
Incorporation of CIP into SLNs leads to controlled release and a superior antibacterial effect of CIP.
American Psychological Association (APA)
Shazly, Gamal A.. 2017. Ciprofloxacin Controlled-Solid Lipid Nanoparticles: Characterization, In Vitro Release, and Antibacterial Activity Assessment. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134551
Modern Language Association (MLA)
Shazly, Gamal A.. Ciprofloxacin Controlled-Solid Lipid Nanoparticles: Characterization, In Vitro Release, and Antibacterial Activity Assessment. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1134551
American Medical Association (AMA)
Shazly, Gamal A.. Ciprofloxacin Controlled-Solid Lipid Nanoparticles: Characterization, In Vitro Release, and Antibacterial Activity Assessment. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134551