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The Oncogenic Role of miR-BART19-3p in Epstein-Barr Virus-Associated Diseases
Joint Authors
Zhang, Qingxun
He, Hongxuan
Luo, Donghua
Xie, Zhengde
Duan, Ziyuan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Accumulating evidence so far has shown that EBV’s miRNAs have been found to be involved in cancer progression.
However, the comprehensive EBV miRNA expression profiles and their biological significance in EBV-associated diseases are not well documented.
A comprehensive profiling of EBV-encoded miRNAs expressed in CAEBV, EBV-HLH, and nasopharyngeal carcinoma (NPC) patients was constructed, and the results showed that miR-BART19-3p was upregulated in all these diseases.
Ectopic expression of miR-BART19-3p induced EBV-negative cell proliferation and suppressed cell apoptosis.
Molecularly, adenomatous polyposis coli (APC) was identified to be a direct target of miR-BART19-3p, and APC mRNA expression was inversely correlated with miR-BART19-3p in CAEBV samples.
Our results demonstrated that miR-BART19-3p contributes to the tumorigenesis of EBV-associated diseases and may be a potential therapeutic target.
American Psychological Association (APA)
Zhang, Qingxun& Luo, Donghua& Xie, Zhengde& He, Hongxuan& Duan, Ziyuan. 2020. The Oncogenic Role of miR-BART19-3p in Epstein-Barr Virus-Associated Diseases. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1134584
Modern Language Association (MLA)
Zhang, Qingxun…[et al.]. The Oncogenic Role of miR-BART19-3p in Epstein-Barr Virus-Associated Diseases. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1134584
American Medical Association (AMA)
Zhang, Qingxun& Luo, Donghua& Xie, Zhengde& He, Hongxuan& Duan, Ziyuan. The Oncogenic Role of miR-BART19-3p in Epstein-Barr Virus-Associated Diseases. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1134584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134584