Identification of microRNA-451a as a Novel Circulating Biomarker for Colorectal Cancer Diagnosis
Joint Authors
Zhang, Zhen
Zhang, Dai
Cui, Yaping
Qiu, Yongsheng
Miao, Changhong
Lu, Xihua
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-27
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Background.
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide.
Successful treatment of CRC relies on accurate early diagnosis, which is currently a challenge due to its complexity and personalized pathologies.
Thus, novel molecular biomarkers are needed for early CRC detection.
Methods.
Gene and microRNA microarray profiling of CRC tissues and miRNA-seq data were analyzed.
Candidate microRNA biomarkers were predicted using both CRC-specific network and miRNA-BD tool.
Validation analyses were carried out to interrogate the identified candidate CRC biomarkers.
Results.
We identified miR-451a as a potential early CRC biomarker circulating in patient’s serum.
The dysregulation of miR-451a was revealed both in primary tumors and in patients’ sera.
Downstream analysis validated the tumor suppressor role of miR-451a and high sensitivity of miR-451a in CRC patients, further confirming its potential role as CRC circulation biomarker.
Conclusion.
The miR-451a is a potential circulating biomarker for early CRC diagnosis.
American Psychological Association (APA)
Zhang, Zhen& Zhang, Dai& Cui, Yaping& Qiu, Yongsheng& Miao, Changhong& Lu, Xihua. 2020. Identification of microRNA-451a as a Novel Circulating Biomarker for Colorectal Cancer Diagnosis. BioMed Research International،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1134602
Modern Language Association (MLA)
Zhang, Zhen…[et al.]. Identification of microRNA-451a as a Novel Circulating Biomarker for Colorectal Cancer Diagnosis. BioMed Research International No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1134602
American Medical Association (AMA)
Zhang, Zhen& Zhang, Dai& Cui, Yaping& Qiu, Yongsheng& Miao, Changhong& Lu, Xihua. Identification of microRNA-451a as a Novel Circulating Biomarker for Colorectal Cancer Diagnosis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1134602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134602