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Rituximab for Treatment of Membranoproliferative Glomerulonephritis and C3 Glomerulopathies
Author
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Membranoproliferative glomerulonephritis (MPGN) is a histological pattern of injury resulting from predominantly subendothelial and mesangial deposition of immunoglobulins or complement factors with subsequent inflammation and proliferation particularly of the glomerular basement membrane.
Recent classification of MPGN is based on pathogenesis dividing MPGN into immunoglobulin-associated MPGN and complement-mediated C3 glomerulonephritis (C3GN) and dense deposit disease (DDD).
Current guidelines suggest treatment with steroids, cytotoxic agents with or without plasmapheresis only for subjects with progressive disease, that is, nephrotic range proteinuria and decline of renal function.
Rituximab, a chimeric B-cell depleting anti-CD20 antibody, has emerged in the last decade as a treatment option for patients with primary glomerular diseases such as minimal change disease, focal-segmental glomerulosclerosis, or idiopathic membranous nephropathy.
However, data on the use of rituximab in MPGN, C3GN, and DDD are limited to case reports and retrospective case series.
Patients with immunoglobulin-associated and idiopathic MPGN who were treated with rituximab showed partial and complete responses in the majorities of cases.
However, rituximab was not effective in few cases of C3GN and DDD.
Despite promising results in immunoglobulin-associated and idiopathic MPGN, current evidence on this treatment remains weak, and controlled and prospective data are urgently needed.
American Psychological Association (APA)
Rudnicki, Michael. 2017. Rituximab for Treatment of Membranoproliferative Glomerulonephritis and C3 Glomerulopathies. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134617
Modern Language Association (MLA)
Rudnicki, Michael. Rituximab for Treatment of Membranoproliferative Glomerulonephritis and C3 Glomerulopathies. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1134617
American Medical Association (AMA)
Rudnicki, Michael. Rituximab for Treatment of Membranoproliferative Glomerulonephritis and C3 Glomerulopathies. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134617