Proteomic Analysis of Human Endometrial Tissues Reveals the Roles of PI3KAKTmTOR Pathway and Tumor Angiogenesis Molecules in the Pathogenesis of Endometrial Cancer
Joint Authors
Liu, Zhen
Hong, Zhipan
Qu, Pengpeng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
As one major gynecological malignancy, endometrial cancer (EC) has been widely studied recently.
However, its pathogenesis is still unclear to date.
In this study, we identified differentially expressed proteins between 30 endometrial cancer tissues and 30 matched normal controls using 2D LC-MS/MS quantitative proteomics.
As a result, we identified 619 differentially expressed proteins among all 2521 proteins being quantified.
Further analyses suggested that the changes of fat, amino acid metabolism, peroxisome, extracellular signal, cytoskeleton, and other signaling or metabolic pathways may be closely related to the development of this cancer.
Particularly, the PI3K/AKT/mTOR pathway-related molecules including PI3K and mTOR, ERK (the molecule of the ERK pathway), SPP1, and ANGPT2 (angiogenesis-related molecules) are highly associated with the pathogenesis of EC, which were reconfirmed by western blot and immunohistochemistry (IHC) analysis.
In summary, our study revealed that the PI3K/AKT/mTOR pathway and tumor angiogenesis molecules contribute to the pathogenesis of endometrial cancer.
American Psychological Association (APA)
Liu, Zhen& Hong, Zhipan& Qu, Pengpeng. 2020. Proteomic Analysis of Human Endometrial Tissues Reveals the Roles of PI3KAKTmTOR Pathway and Tumor Angiogenesis Molecules in the Pathogenesis of Endometrial Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134625
Modern Language Association (MLA)
Liu, Zhen…[et al.]. Proteomic Analysis of Human Endometrial Tissues Reveals the Roles of PI3KAKTmTOR Pathway and Tumor Angiogenesis Molecules in the Pathogenesis of Endometrial Cancer. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1134625
American Medical Association (AMA)
Liu, Zhen& Hong, Zhipan& Qu, Pengpeng. Proteomic Analysis of Human Endometrial Tissues Reveals the Roles of PI3KAKTmTOR Pathway and Tumor Angiogenesis Molecules in the Pathogenesis of Endometrial Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134625