YCl3 Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats
Joint Authors
Wu, Longhuo
Tian, Yuantong
Ding, Yechun
Zeng, Zhaoyi
Shuai, Ping
Lan, Haiying
Zhu, Xianshen
Zhong, Yi
Fan, Xiaona
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The pollutants rare earth elements (REEs) have posed great threats to human health.
To investigate the cytotoxicity of yttrium (Y), a model that rats have free access to water containing YCl3 for 6 months is utilized.
The results showed that YCl3 treatment promoted neuronal cell apoptosis by upregulating the proapoptotic factors Bax, caspase-3, Cyto c, and DAPK and by downregulating the antiapoptotic factors Bcl-2 and XIAP at both mRNA and protein levels.
Conclusively, YCl3 exhibited cytotoxicity and promoted neuronal cell death by the induction of apoptotic pathways.
American Psychological Association (APA)
Ding, Yechun& Tian, Yuantong& Zeng, Zhaoyi& Shuai, Ping& Lan, Haiying& Zhu, Xianshen…[et al.]. 2017. YCl3 Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1134627
Modern Language Association (MLA)
Ding, Yechun…[et al.]. YCl3 Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1134627
American Medical Association (AMA)
Ding, Yechun& Tian, Yuantong& Zeng, Zhaoyi& Shuai, Ping& Lan, Haiying& Zhu, Xianshen…[et al.]. YCl3 Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1134627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134627
