Protective Effect of a Novel Polysaccharide from Lonicera japonica on Cardiomyocytes of Mice Injured by Hydrogen Peroxide
Joint Authors
Zhou, Xiaonan
He, Gui
Ma, Jinming
Tang, Min
Tian, Geng
Gong, Xun
Zhang, Huajun
Kui, Ling
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Lonicera japonica is a traditional Chinese herbal medicine with antioxidation, anti-inflammatory, antibacterial, and immunoregulation functions.
A method to isolate polysaccharides from Lonicera japonica (LJP) has been reported previously by our group.
We also reported previously that LJP was consisted of 6 types of monosaccharides and had the characteristic absorption of typical polysaccharides.
In this study, we investigated the protective effect of LJP on cardiomyocytes of mice injured by hydrogen peroxide (H2O2).
The results showed that LJP can increase the cardiomyocyte viability and the activities of the enzyme (SOD, CAT, GSH-Px, AST, CPK, and LDH) in cardiomyocytes of mice injured by hydrogen peroxide.
The results of intracellular ROS contents showed that a high dose (40 μg mL-1) of LJP had the best effects on protecting the cardiomyocytes of mice injured by H2O2.
In addition, the measurement results of the cardiomyocyte apoptosis and the activity of caspase-3, caspase-8, and caspase-9 in cardiomyocytes confirmed this conclusion from another perspective.
American Psychological Association (APA)
Zhou, Xiaonan& He, Gui& Ma, Jinming& Tang, Min& Tian, Geng& Gong, Xun…[et al.]. 2020. Protective Effect of a Novel Polysaccharide from Lonicera japonica on Cardiomyocytes of Mice Injured by Hydrogen Peroxide. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134628
Modern Language Association (MLA)
Zhou, Xiaonan…[et al.]. Protective Effect of a Novel Polysaccharide from Lonicera japonica on Cardiomyocytes of Mice Injured by Hydrogen Peroxide. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1134628
American Medical Association (AMA)
Zhou, Xiaonan& He, Gui& Ma, Jinming& Tang, Min& Tian, Geng& Gong, Xun…[et al.]. Protective Effect of a Novel Polysaccharide from Lonicera japonica on Cardiomyocytes of Mice Injured by Hydrogen Peroxide. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134628