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Gene-Gene Interaction Analysis for the Survival Phenotype Based on the Kaplan-Meier Median Estimate
Joint Authors
Park, Taesung
Park, Mira
Lee, Seungyeoun
Lee, Jung Wun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In this study, we propose a simple and computationally efficient method based on the multifactor dimensional reduction algorithm to identify gene-gene interactions associated with the survival phenotype.
The proposed method, referred to as KM-MDR, uses the Kaplan-Meier median survival time as a classifier.
The KM-MDR method classifies multilocus genotypes into a binary attribute for high- or low-risk groups using median survival time and replaces balanced accuracy with log-rank test statistics as a score to determine the best model.
Through intensive simulation studies, we compared the power of KM-MDR with that of Surv-MDR, Cox-MDR, and AFT-MDR.
It was found that KM-MDR has a similar power to that of Surv-MDR, with less computing time, and has comparable power to that of Cox-MDR and AFT-MDR, even when there is a covariate effect.
Furthermore, we apply KM-MDR to a real dataset of ovarian cancer patients from The Cancer Genome Atlas (TCGA).
American Psychological Association (APA)
Park, Mira& Lee, Jung Wun& Park, Taesung& Lee, Seungyeoun. 2020. Gene-Gene Interaction Analysis for the Survival Phenotype Based on the Kaplan-Meier Median Estimate. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134635
Modern Language Association (MLA)
Park, Mira…[et al.]. Gene-Gene Interaction Analysis for the Survival Phenotype Based on the Kaplan-Meier Median Estimate. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1134635
American Medical Association (AMA)
Park, Mira& Lee, Jung Wun& Park, Taesung& Lee, Seungyeoun. Gene-Gene Interaction Analysis for the Survival Phenotype Based on the Kaplan-Meier Median Estimate. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134635