Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer

Joint Authors

Jiang, Yue
Jin, Guangfu
Ma, Hongxia
Hu, Zhibin
Shen, Hongbing
Dai, Juncheng
Chen, Jiaping
Zhou, Jing
Liu, Sijun
Gu, Yayun

Source

BioMed Research International

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-06-12

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Variants in microRNA genes may affect their expression by interfering with the microRNA maturation process and may substantially contribute to the risk of breast cancer.

Recent studies have identified miR-10b as an interesting candidate because of its close association with the metastatic behavior of breast cancer.

However, the roles of miR-10b-related single nucleotide polymorphisms in breast cancer susceptibility remain unclear.

This case-control study evaluated the associations between variants in the upstream transcription regulation region of miR-10b and the risk of breast cancer among Chinese women.

Seven potentially functional SNPs were investigated using genotyping assays.

The potential biological functions of the identified positive SNPs were further evaluated using in silico databases.

We found that rs4078756, which was located at the promoter region of miR-10b, was significantly associated with breast cancer risk (rs4078756 AG/GG versus AA, adjusted odds ratio: 1.17, 95% confidence interval: 1.02–1.35).

The other six single nucleotide polymorphisms exhibited negative associations.

Based on the in silico prediction, rs4078756 potentially regulated miR-10b expression through promoter activation or repression.

These findings indicate that a potentially functional SNP (rs4078756) in the promoter region of miR-10b may contribute to breast cancer susceptibility among Chinese women.

American Psychological Association (APA)

Chen, Jiaping& Jiang, Yue& Zhou, Jing& Liu, Sijun& Gu, Yayun& Jin, Guangfu…[et al.]. 2017. Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134678

Modern Language Association (MLA)

Chen, Jiaping…[et al.]. Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1134678

American Medical Association (AMA)

Chen, Jiaping& Jiang, Yue& Zhou, Jing& Liu, Sijun& Gu, Yayun& Jin, Guangfu…[et al.]. Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134678

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1134678