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MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39
Joint Authors
Guo, Rende
Gu, Jianhua
Zhang, Zhibin
Wang, Yi
Gu, Chuan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Emerging evidence shows that microRNAs (miRNAs) play important roles in the regulation of various biological and pathologic processes in human cancers and the aberrant expression of miRNAs contributes to the tumor development.
In this study, our findings indicate that miR-451 is significantly overexpressed in pancreatic cancer tissues and cell lines and elevated expression of miR-451 contributes to promoted cell viability (in vitro and in vivo).
Moreover, overexpression of miR-451 is closely linked to poor prognosis and lymphatic metastasis.
Inhibition of miR-451 dramatically suppresses cell viability and invasion, promotes cell apoptosis, and induces cell cycle arrest.
Furthermore, miR-451 directly targets CAB39 and negatively regulates its expression and inhibition of CAB39 contributes to the promoted cell viability and invasion.
Our findings improve our understanding of the function of miR-451 in the identification and therapy of pancreatic cancer.
American Psychological Association (APA)
Guo, Rende& Gu, Jianhua& Zhang, Zhibin& Wang, Yi& Gu, Chuan. 2017. MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134688
Modern Language Association (MLA)
Guo, Rende…[et al.]. MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1134688
American Medical Association (AMA)
Guo, Rende& Gu, Jianhua& Zhang, Zhibin& Wang, Yi& Gu, Chuan. MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134688