Thyroid Dysfunction in Non-Interferon Treated Hepatitis C Patients Residing in Hepatitis Endemic Area

Abstract EN

Background.

Association of thyroid dysfunction (TD) with interferon treatment of HCV is well known to clinicians.

However, a few studies have highlighted the role of hepatitis C virus per se in the development of TD.

The aim of this study was to know the prevalence of TD in non-interferon treated HCV infected patients referred for thyroid function testing.

Patients and Methods.

Among 557 ELISA-positive HCV patients 446 (341 females, 105 males) were selected for this study.

Serums FT4, FT3, and TSH were determined by radioimmunoassay method.

Results.

TD was detected in 15.2% of patients: 9.0% hypothyroidism and 6.3% hyperthyroidism.

In increasing order subclinical hypothyroidism, overt hypothyroidism, overt hyperthyroidism, and subclinical hyperthyroidism were found in 4.7%, 4.3%, 3.6%, and 2.7% patients, respectively.

Overall TD was more common in female than in male HCV patients but the difference was not significant (16.1% versus 12.4%; p=0.648).

Hyperthyroidism and subclinical hypothyroidism were slightly more common in female and overall hypothyroidism and overt hypothyroidism in male patients but the difference was not statistically significant (p>0.05).

The incidence of TD was relatively high in patients above 36 years (median age) but the difference was not statistically significant either collectively or in gender base groups (p>0.05).

Conclusion.

Prior to interferon treatment, HCV infection itself causes biochemical thyroid dysfunction in 15.2% of local HCV patients.