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Recent Advances of Curcumin in the Prevention and Treatment of Renal Fibrosis
Joint Authors
Li, Yu
Liu, Chenyue
Sun, Xuejiao
Liu, Yi
Li, Cheng
Wang, Xiting
Zhu, Ruyuan
Liu, Haixia
Wang, Lili
Ma, Rufeng
Zhang, Dong-wei
Fu, Min
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Curcumin, a polyphenol derived from the turmeric, has received attention as a potential treatment for renal fibrosis primarily because it is a relatively safe and inexpensive compound that contributes to kidney health.
Here, we review the literatures on the applications of curcumin in resolving renal fibrosis in animal models and summarize the mechanisms of curcumin and its analogs (C66 and (1E,4E)-1,5-bis(2-bromophenyl) penta-1,4-dien-3-one(B06)) in preventing inflammatory molecules release and reducing the deposition of extracellular matrix at the priming and activation stage of renal fibrosis in animal models by consulting PubMed and Cnki databases over the past 15 years.
Curcumin exerts antifibrotic effect through reducing inflammation related factors (MCP-1, NF-κB, TNF-α, IL-1β, COX-2, and cav-1) and inducing the expression of anti-inflammation factors (HO-1, M6PRBP1, and NEDD4) as well as targeting TGF-β/Smads, MAPK/ERK, and PPAR-γ pathways in animal models.
As a food derived compound, curcumin is becoming a promising drug candidate for improving renal health.
American Psychological Association (APA)
Sun, Xuejiao& Liu, Yi& Li, Cheng& Wang, Xiting& Zhu, Ruyuan& Liu, Chenyue…[et al.]. 2017. Recent Advances of Curcumin in the Prevention and Treatment of Renal Fibrosis. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134724
Modern Language Association (MLA)
Sun, Xuejiao…[et al.]. Recent Advances of Curcumin in the Prevention and Treatment of Renal Fibrosis. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1134724
American Medical Association (AMA)
Sun, Xuejiao& Liu, Yi& Li, Cheng& Wang, Xiting& Zhu, Ruyuan& Liu, Chenyue…[et al.]. Recent Advances of Curcumin in the Prevention and Treatment of Renal Fibrosis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134724