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Abundance of Multidrug Resistance Efflux Pumps in the Urinary Metagenome of Kidney Transplant Patients
Joint Authors
Ranjan, Ravi
Rani, Asha
Finn, Patricia W.
Perkins, David L.
Metwally, Ahmed A.
Brennan, Daniel C.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Antibiotic resistance including the emergence of multidrug resistant microbes has become a public health crisis.
In this study, we analyzed the antibiotic resistance genes (ARGs) in the urinary metagenome of the kidney transplant and healthy subjects using metagenomic shotgun sequencing.
Our data suggest an increased abundance of antibiotic resistance genes in the kidney transplant subjects.
In addition, the antibiotic resistance genes identified in the transplant subjects were predominantly composed of multidrug efflux pumps (MDEPs) which are evolutionarily ancient, commonly encoded on chromosomes rather than plasmids, and have a low rate of mutation.
Since the MDEPs had a low abundance in the healthy subjects, we speculate that the MDEPs may enhance the fitness of bacteria to survive in the high stress environment of transplantation that includes multiple stressors including surgery, antibiotics, and immunosuppressive agents.
American Psychological Association (APA)
Rani, Asha& Ranjan, Ravi& Metwally, Ahmed A.& Brennan, Daniel C.& Finn, Patricia W.& Perkins, David L.. 2020. Abundance of Multidrug Resistance Efflux Pumps in the Urinary Metagenome of Kidney Transplant Patients. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134759
Modern Language Association (MLA)
Rani, Asha…[et al.]. Abundance of Multidrug Resistance Efflux Pumps in the Urinary Metagenome of Kidney Transplant Patients. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1134759
American Medical Association (AMA)
Rani, Asha& Ranjan, Ravi& Metwally, Ahmed A.& Brennan, Daniel C.& Finn, Patricia W.& Perkins, David L.. Abundance of Multidrug Resistance Efflux Pumps in the Urinary Metagenome of Kidney Transplant Patients. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134759