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A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix
Joint Authors
Zhou, Mengting
Hu, Naihua
Liu, Meichen
Deng, Ying
He, Linfeng
Guo, Chaocheng
Zhao, Xingtao
Li, Yunxia
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-22
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease, a type of metabolic syndrome, continues to rise globally.
Currently, there is no approved drug for its treatment.
Improving lifestyle and exercise can alleviate symptoms, but patients’ compliance is poor.
More and more studies have shown the potential of Polygoni Multiflori Radix (PMR) in the treatment of NAFLD and metabolic syndrome.
Therefore, this paper reviews the pharmacological effects of PMR and its main chemical components (tetrahydroxystilbene glucoside, emodin, and resveratrol) on NAFLD.
PMR can inhibit the production of fatty acids and promote the decomposition of triglycerides, reduce inflammation, and inhibit the occurrence of liver fibrosis.
At the same time, it maintains an oxidation equilibrium status in the body, to achieve the therapeutic purpose of NAFLD and metabolic syndrome.
Although more standardized studies and clinical trials are needed to confirm its efficacy, PMR may be a potential drug for the treatment of NAFLD and its complications.
However, the occurrence of adverse reactions of PMR has affected its extensive clinical application.
Therefore, it is necessary to further study its toxicity mechanism, enhance efficacy and control toxicity, and even reduce toxicity, which will contribute to the safe clinical use of PMR.
American Psychological Association (APA)
Zhou, Mengting& Hu, Naihua& Liu, Meichen& Deng, Ying& He, Linfeng& Guo, Chaocheng…[et al.]. 2020. A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix. BioMed Research International،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1134789
Modern Language Association (MLA)
Zhou, Mengting…[et al.]. A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix. BioMed Research International No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1134789
American Medical Association (AMA)
Zhou, Mengting& Hu, Naihua& Liu, Meichen& Deng, Ying& He, Linfeng& Guo, Chaocheng…[et al.]. A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1134789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134789