Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila
Joint Authors
Jian, Li
Chang, Hong
Wu, Chenxi
Wang, Sitong
Wu, Fanwu
Ye, Bin
Zhang, Shiping
Wang, Xingjun
Xu, Qian
Li, Guowang
Zhang, Menglong
Wang, Shuai
Jia, Yongsen
Jiang, Chunhua
La, Xiaojin
Zhao, Zixue
Li, Peng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Xuefu Zhuyu Decoction (XFZYD), a Traditional Chinese Medicine (TCM) decoction mainly for treating blood stasis syndrome, has been widely investigated and applied in clinic and in laboratory.
XFZYD contains 11 herbs and has been identified to promoting blood circulation to remove blood stasis for cardiovascular disease.
Meanwhile, blood stasis is directly related to malignant tumor according to TCM basic theory.
However, the effects of XFZYD on tumor metastasis and the underlying mechanisms are still largely unknown.
Here, we employed well-established Drosophila cell migration and tumor invasion models to explore whether XFZYD has the anticancer activity on tumor metastasis in vivo.
Our work has demonstrated that XFZYD could suppress cell migration and tumor invasion at the moderate concentrations.
In addition, XFZYD altered the expression of MMP1, β-integrin, and E-cadherin to impede cell migration.
Moreover, XFZYD inhibited ocular tumor invasion presumably by reducing the activity of Notch signaling.
Together, these evidences reveal a positive role of XFZYD in suppressing cell migration and tumor metastasis, providing the potential drug targets and key clues for cancer clinical treatment strategies.
American Psychological Association (APA)
Wang, Sitong& Wu, Fanwu& Ye, Bin& Zhang, Shiping& Wang, Xingjun& Xu, Qian…[et al.]. 2020. Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134792
Modern Language Association (MLA)
Wang, Sitong…[et al.]. Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1134792
American Medical Association (AMA)
Wang, Sitong& Wu, Fanwu& Ye, Bin& Zhang, Shiping& Wang, Xingjun& Xu, Qian…[et al.]. Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134792