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Comparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: The Hemoglobin Case
Joint Authors
Liang, Zhongjie
Di Paola, Luisa
Giuliani, Alessandro
Hu, Guang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-22
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The overall topology and interfacial interactions play key roles in understanding structural and functional principles of protein complexes.
Elastic Network Model (ENM) and Protein Contact Network (PCN) are two widely used methods for high throughput investigation of structures and interactions within protein complexes.
In this work, the comparative analysis of ENM and PCN relative to hemoglobin (Hb) was taken as case study.
We examine four types of structural and dynamical paradigms, namely, conformational change between different states of Hbs, modular analysis, allosteric mechanisms studies, and interface characterization of an Hb.
The comparative study shows that ENM has an advantage in studying dynamical properties and protein-protein interfaces, while PCN is better for describing protein structures quantitatively both from local and from global levels.
We suggest that the integration of ENM and PCN would give a potential but powerful tool in structural systems biology.
American Psychological Association (APA)
Hu, Guang& Di Paola, Luisa& Liang, Zhongjie& Giuliani, Alessandro. 2017. Comparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: The Hemoglobin Case. BioMed Research International،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1134807
Modern Language Association (MLA)
Hu, Guang…[et al.]. Comparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: The Hemoglobin Case. BioMed Research International No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1134807
American Medical Association (AMA)
Hu, Guang& Di Paola, Luisa& Liang, Zhongjie& Giuliani, Alessandro. Comparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: The Hemoglobin Case. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1134807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134807