The New Biomarker for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Based on Public Database Mining
Joint Authors
Xiong, Xiaoxing
Ding, Hao
Fan, Guan-Lan
Yi, Yue-Xiong
Chen, Yu-Rou
Wang, Jing-Tao
Zhang, Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To reconstruct the ceRNA biological network of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) and to select an appropriate mRNA as a biomarker that could be used for CESC early diagnosis and prognosis evaluation.
We downloaded CESC data from the TCGA public database, and statistical analysis was conducted with the R software to find out differential expressed genes encoding for lncRNAs, miRNAs, and mRNAs.
The differentially expressed mRNAs (DEmRNAs) screened in the ceRNA network were analyzed for survival to find the mRNAs with significantly linked to the survival prognosis.
These mRNAs were searched in the Pathological Atlas to identify the final appropriate mRNAs.
Differential expression analysis revealed 773 lncRNAs, 94 miRNAs, and 2466 mRNAs.
Survival analysis of DEmRNAs in the ceRNA network indicated that ADGRF4, ANXA8L1, HCAR3, IRF6, and PDE2A (P<0.05) were negatively correlated with survival time.
Verification of these six DEmRNAs in the Pathology Atlas indicated that PDE2A was a possible biomarker for CESC patients.
PDE2A might be a biomarker for early diagnosis and prognosis evaluation of CESC patients, but due to the lack of available data, further studies may be needed for confirmation.
American Psychological Association (APA)
Ding, Hao& Xiong, Xiaoxing& Fan, Guan-Lan& Yi, Yue-Xiong& Chen, Yu-Rou& Wang, Jing-Tao…[et al.]. 2020. The New Biomarker for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Based on Public Database Mining. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134809
Modern Language Association (MLA)
Ding, Hao…[et al.]. The New Biomarker for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Based on Public Database Mining. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1134809
American Medical Association (AMA)
Ding, Hao& Xiong, Xiaoxing& Fan, Guan-Lan& Yi, Yue-Xiong& Chen, Yu-Rou& Wang, Jing-Tao…[et al.]. The New Biomarker for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Based on Public Database Mining. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134809