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Dab1 Contributes to Angiotensin II-Induced Apoptosis via p38 Signaling Pathway in Podocytes
Joint Authors
Gao, Zhao
Chen, Xinghua
Zhu, Kai
Zeng, Ping
Ding, Guohua
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Numerous studies have found that angiotensin II (Ang II) participates in podocyte apoptosis and exacerbates progression of end-stage kidney disease (ESKD).
However, its underlying mechanism remains largely unexplored.
As a homolog of Drosophila disabled (Dab) protein, Dab1 plays a vital role in cytoskeleton, neuronal migration, and proliferation.
In the present study, our data revealed that Ang II-infused rats developed hypertension, proteinuria, and podocyte injury accompanied by Dab1 phosphorylation and increased reelin expression in kidney.
Moreover, Ang II induced podocyte apoptosis in vitro.
Dab1 phosphorylation and reelin expression in podocytes were increased after exposure to Ang II.
Conversely, Dab1 small interfering RNA (siRNA) exerted protective effects on Ang II-induced podocyte apoptosis, resulting in decreased p38 phosphorylation and reelin expression.
These results indicated that Dab1 mediated Ang II-induced podocyte apoptosis via p38 signaling pathway.
American Psychological Association (APA)
Gao, Zhao& Chen, Xinghua& Zhu, Kai& Zeng, Ping& Ding, Guohua. 2017. Dab1 Contributes to Angiotensin II-Induced Apoptosis via p38 Signaling Pathway in Podocytes. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134813
Modern Language Association (MLA)
Gao, Zhao…[et al.]. Dab1 Contributes to Angiotensin II-Induced Apoptosis via p38 Signaling Pathway in Podocytes. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1134813
American Medical Association (AMA)
Gao, Zhao& Chen, Xinghua& Zhu, Kai& Zeng, Ping& Ding, Guohua. Dab1 Contributes to Angiotensin II-Induced Apoptosis via p38 Signaling Pathway in Podocytes. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134813