2-Methacryloyloxyethyl Phosphorylcholine Polymer Coating Inhibits Bacterial Adhesion and Biofilm Formation on a Suture: An In Vitro and In Vivo Study
Joint Authors
Miyamoto, Hiroshi
Tanaka, Sakae
Ishihara, Kazuhiko
Moro, Toru
Shobuike, Takeo
Kaneko, Taizo
Saito, Taku
Matsuda, Junpei
Fukazawa, Kyoko
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Initial bacterial adhesion to medical devices and subsequent biofilm formation are known as the leading causes of surgical site infection (SSI).
Therefore, inhibition of bacterial adhesion and biofilm formation on the surface of medical devices can reduce the risk of SSIs.
In this study, a highly hydrophilic, antibiofouling surface was prepared by coating the bioabsorbable suture surface with poly(2-methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate) (PMB).
The PMB-coated and noncoated sutures exhibited similar mechanical strength and surface morphology.
The effectiveness of the PMB coating on the suture to suppress adhesion and biofilm formation of methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus was investigated both in vitro and in vivo.
The bacterial adhesion test revealed that PMB coating significantly reduced the number of adherent bacteria, with no difference in the number of planktonic bacteria.
Moreover, fluorescence microscopy and scanning electron microscopy observations of adherent bacteria on the suture surface after contact with bacterial suspension confirmed PMB coating-mediated inhibition of biofilm formation.
Additionally, we found that the PMB-coated sutures exhibited significant antibiofouling effects in vivo.
In conclusion, PMB-coated sutures demonstrated bacteriostatic effects associated with a highly hydrophilic, antibiofouling surface and inhibited bacterial adhesion and biofilm formation.
Therefore, PMB-coated sutures could be a new alternative to reduce the risk of SSIs.
American Psychological Association (APA)
Kaneko, Taizo& Saito, Taku& Shobuike, Takeo& Miyamoto, Hiroshi& Matsuda, Junpei& Fukazawa, Kyoko…[et al.]. 2020. 2-Methacryloyloxyethyl Phosphorylcholine Polymer Coating Inhibits Bacterial Adhesion and Biofilm Formation on a Suture: An In Vitro and In Vivo Study. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134849
Modern Language Association (MLA)
Kaneko, Taizo…[et al.]. 2-Methacryloyloxyethyl Phosphorylcholine Polymer Coating Inhibits Bacterial Adhesion and Biofilm Formation on a Suture: An In Vitro and In Vivo Study. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1134849
American Medical Association (AMA)
Kaneko, Taizo& Saito, Taku& Shobuike, Takeo& Miyamoto, Hiroshi& Matsuda, Junpei& Fukazawa, Kyoko…[et al.]. 2-Methacryloyloxyethyl Phosphorylcholine Polymer Coating Inhibits Bacterial Adhesion and Biofilm Formation on a Suture: An In Vitro and In Vivo Study. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134849