First Insight into the Molecular Epidemiology of Mycobacterium tuberculosis Isolates from the Minority Enclaves of Southwestern China
Joint Authors
Pang, Yu
Chen, Lianyong
Ma, Li
Yang, Huijuan
Ru, Haohao
Yang, Xing
Yan, Shuangqun
Jia, Mao
Xu, Lin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Yunnan is a province located in southwestern China.
The aim of this study was to investigate the genetic diversity of Mycobacterium tuberculosis (MTB) strains circulating in Yunnan Province.
We used spoligotyping and a 12-locus high-resolution VNTR set to identify a total of 271 MTB isolates collected from six prefectures’ Yunnan.
All the 271 patients were classified as 11 different ethnic groups, including 133 Han patients (49.1%) and 138 minority patients (50.9%).
Spoligotyping analyses revealed that the largest two spoligotypes were SIT1 (Beijing family, n=136) and SIT53 (T family, n=35).
Statistical analysis indicated that the proportion of Beijing genotype in Qujing was significantly higher than that in the ethnic enclaves (P≤0.01).
Compared with the percentage of Beijing-family isolates from patients under 25 years of age (72.7%), those from patients aged 45~64 years (44.6%, P<0.01) and older than 64 years (48.1%) (P=0.04) were significantly lower.
Beijing genotype strains (23.8%, 36/151) showed higher clustering rate than non-Beijing genotype strains (16/120, 13.3%, P=0.029).
In conclusion, our data demonstrated that the Beijing genotype was the predominant genotype in Yunnan Province.
The distribution of Beijing genotype strains showed geographic diversity.
In addition, Beijing genotype was associated with recent transmission rather than drug resistance.
American Psychological Association (APA)
Chen, Lianyong& Pang, Yu& Ma, Li& Yang, Huijuan& Ru, Haohao& Yang, Xing…[et al.]. 2017. First Insight into the Molecular Epidemiology of Mycobacterium tuberculosis Isolates from the Minority Enclaves of Southwestern China. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134853
Modern Language Association (MLA)
Chen, Lianyong…[et al.]. First Insight into the Molecular Epidemiology of Mycobacterium tuberculosis Isolates from the Minority Enclaves of Southwestern China. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1134853
American Medical Association (AMA)
Chen, Lianyong& Pang, Yu& Ma, Li& Yang, Huijuan& Ru, Haohao& Yang, Xing…[et al.]. First Insight into the Molecular Epidemiology of Mycobacterium tuberculosis Isolates from the Minority Enclaves of Southwestern China. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134853