Relative Telomere Length in Peripheral Blood Cells and Hypertension Risk among Mine Workers: A Case-Control Study in Chinese Coal Miners
Joint Authors
Wang, Qian
Jia, Jin
Li, Ben
Yu, Sheng-nan
Chen, Shi-qi
Fan, Guo-quan
Pan, Wei-zhe
Qiang, Mei
Qiu, Yu-lan
Wang, Tong
Ma, Li
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hypertension is a common chronic disease in middle-aged and elderly people and is an important risk factor for many cardiovascular diseases.
Its pathogenesis remains unclear.
Epidemiological studies have found that the loss of telomere length in peripheral blood cells can increase the risk of coronary heart disease, myocardial infarction, and other diseases.
However, a correlation between loss of telomere length and hypertension has not been established.
In this study, we aimed to explore the association between telomere length and the risk of essential hypertension (EH) in Chinese coal miners.
A case-control study was performed with 215 EH patients and 222 healthy controls in a large coal mining group located in North China.
Face-to-face interviews were conducted by trained staff with the necessary medical knowledge.
Relative telomere length (RTL) was measured by a quantitative real-time PCR assay using DNA extracted from peripheral blood.
In the control group, the age-adjusted RTL was statistically significantly lower in miners performing hard physical labour compared with nonphysical labour (P=0.043).
A significantly shorter age-adjusted RTL was found in the control group of participants who consumed alcohol regularly compared with those who do not consume alcohol (P=0.024).
Age-adjusted RTL was negatively correlated with body mass index (BMI) and alcohol consumption.
Hypertension was also found to be significantly correlated with factors such as age, BMI, alcohol consumption, smoking, and tea consumption.
Our results suggest that RTL is associated with hypertension in coal miners.
American Psychological Association (APA)
Yu, Sheng-nan& Chen, Shi-qi& Fan, Guo-quan& Pan, Wei-zhe& Jia, Jin& Wang, Qian…[et al.]. 2020. Relative Telomere Length in Peripheral Blood Cells and Hypertension Risk among Mine Workers: A Case-Control Study in Chinese Coal Miners. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134878
Modern Language Association (MLA)
Yu, Sheng-nan…[et al.]. Relative Telomere Length in Peripheral Blood Cells and Hypertension Risk among Mine Workers: A Case-Control Study in Chinese Coal Miners. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1134878
American Medical Association (AMA)
Yu, Sheng-nan& Chen, Shi-qi& Fan, Guo-quan& Pan, Wei-zhe& Jia, Jin& Wang, Qian…[et al.]. Relative Telomere Length in Peripheral Blood Cells and Hypertension Risk among Mine Workers: A Case-Control Study in Chinese Coal Miners. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134878